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KMID : 0390119920320010119
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Journal of Pusan Medical College
1992 Volume.32 No. 1 p.119 ~ p.132
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The Effect of Ketoconazole Shampoo and Systemic Itraconzole on Pityrosporum of Scalp
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Abstract
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A normal flora of the skin, pityrosporum yeast, is thought to be a etiologic factor of seborrheic dermatitis on scalp and dandruff.
Author observed the clinical and mycologic finding of 28 patients of seborrheic dermatitis and dandruff who have visited Pusan National University Hospital, and studied the effect of ketoconazole shampoo and systemic itraconazole on pityrosporum
and
clinical symptom of the scalp.
The result were as follows :
1. In the group of patients treated with ketoconazole shampoo, they showed clinical improvement and decreased score of pityrosporum score and hyphae after treatment.
2. In the group of patients treated with systemic itraconazole, they showed clinical improvement, but did not showed decreased score of pityrosporum spore and hyphae.
3. In the control group, there were no visible change of clinical and mycologic findings.
Therefore, it can be suggested that, ketoconazole shampoo may be better than systemic itraconazole in the treatment of dandruff and seborrheic dermatitis of the scalp.
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